Nevermind, I figured it out. The process is different than other Lexus models and the instructions aren't the clearest but if you follow picture diagrams in manual its a lot easier. 
If the mrs has her keys in her purse and I have my fob in my pocket while driving. Pretty normal, no?Not sure, haven't tried it. You might be able to program both fobs to certain seat setting. But why would u have both fobs in the car?